Daily Archives: February 8, 2019

Deregulation of intestinal microRNAs (miRNAs) have been reported in adult and, in the last years, also in pediatric patients with Crohn’s disease (CD). We performed a literature search and chose 4 miRNAs from five relevant studies as candidates for a… Continue reading →

Intestinal epithelial barrier dysfunction is considered as a risk factor in the pathogenesis of Crohn’s disease (CD), and since there is no FDA approved therapy available, there is a need for identifying a relevant model to study and test therapies t… Continue reading →

Colonic epithelium forms a selective barrier between lumen and colonic mucosa. The integrity of colonic epithelium is maintained by cell proliferation, migration and expression of cellular junctions. A compromised colonic epithelium contributes to colo… Continue reading →

Mucosal barrier dysfunction to luminal microbes plays a crucial role in the development of intestinal inflammation in inflammatory bowel disease (IBD). Recently, intestinal epithelial cell (IEC) death resulting from a form of innate immune activation c… Continue reading →

Although the composition of the gut microbiota has been shown to be influenced by host genetics and environmental factors, the effects of the host on the functions of microbial communities remain poorly understood. Intestinal epithelial cells (IECs) ex… Continue reading →

Characterization of Crohn’s disease (CD) includes susceptible mucosal surfaces via abnormal intestinal permeability caused by either deregulated interactions between the bacterial flora and surface epithelial cells or an overwhelming host immune resp… Continue reading →

Locally injected mesenchymal stem cells (MSCs) are now an approved therapy in European Union for perianal Crohn’s disease (CD) fistulas, however, clinical studies have shown limited efficacy of systemic MSC therapy for luminal CD. Thus, we studied th… Continue reading →

Biotin deficiency is often overlooked in patients with Inflammatory Bowel Disease, but it may have profound implications in the GI tract. Biotin is a water-soluble vitamin that must be obtained from exogenous sources and is involved in the metabolism o… Continue reading →

Inflammatory bowel diseases (IBD) are chronic intestinal diseases affecting over 1.4 million Americans. Children and adolescents typically have more severe disease and are more likely to display extra-intestinal effects, including psychosocial deficits… Continue reading →

Advances in studying the onset and progression of ulcerative colitis (UC) suggest that both diet and microbiome play a critical role in the progression of disease, though no causal link has been found. Lactobacillus species found in the microbiome prod… Continue reading →