Daily Archives: February 8, 2019
P135 ORALLY ADMINISTERED FOLH1/GCPII INHIBITORS AS NOVEL THERAPEUTICS IN INFLAMMATORY BOWEL DISEASE (IBD)
The folate hydrolase gene (FOLH1), which encodes for the enzyme glutamate carboxypeptidase II (GCPII), has been implicated in the pathogenesis of inflammatory bowel disease (IBD) where it exhibits a robust 300-1000% increase in enzymatic activity in in… Continue reading
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P136 ELTANEXOR, AN EXPORTIN-1 INHIBITOR, RAPIDLY DECREASES INFLAMMATION AND IMPROVES OUTCOMES IN VITRO AND IN A DSS MODEL OF IBD
Crohn’s disease and ulcerative colitis are inflammatory bowel diseases (IBD) leading to abdominal pain, severe diarrhea, fatigue and weight loss. Over 3.5 million Americans and Europeans are estimated to have IBD, yet there is currently no cure, maki… Continue reading
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P137 LOCAL CRAC CHANNEL BLOCKADE TREATS COLITIS IN MICE
The Ca2+ release activated Ca2+ (CRAC) channel is an exciting new pharmacological target for the treatment of Inflammatory Bowel Disease (IBD) because it is upstream in the inflammatory cascade and absolutely necessary for immune responses. Calcium-sel… Continue reading
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P139 OLORINAB, A PERIPHERALLY RESTRICTED, HIGHLY SELECTIVE AGONIST OF THE CANNABINOID RECEPTOR TYPE 2 FOR THE MANAGEMENT OF VISCERAL PAIN IN INFLAMMATORY BOWEL DISEASE (IBD) – PRECLINICAL AND EARLY CLINICAL DEVELOPMENT
Abdominal pain is common and persistent in patients with IBD. Available anti-inflammatory treatments often fail to relieve pain despite disease remission. Cannabinoid receptor agonists have shown efficacy in visceral pain, but development has been limi… Continue reading
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05 SUSTAINED EXPRESSION OF GLUCOCORTICOID-INDUCED LEUCINE ZIPPER (GILZ) MARKS A POPULATION OF FUNCTIONALLY IMMATURE INTESTINAL REGULATORY T CELLS IN FEMALE CROHN’S DISEASE PATIENTS
In addition to its classic roles in sexual development and function, estrogen (“E2”) is an important immune regulator. The impact of E2 in a given cell is determined by the relative contribution of signaling downstream of two ligand-activated nucle… Continue reading
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16 DIETARY PECTIN ALLEVIATES CHRONIC COLITIS BY PROMOTING NLRC4-MEDIATED IL-1RA PRODUCTION
Dietary soluble fibers have many beneficial effects on gastrointestinal (GI) health; however, the mechanisms by which these fibers attenuate intestinal inflammation during colitis remains elusive. We propose that fiber-derived gut metabolites diminish … Continue reading
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24 A SPECIFIC GENE-MICROBE INTERACTION DRIVES THE DEVELOPMENT OF EARLY-ONSET CROHN’S DISEASE-LIKE COLITIS
Crohn’s disease (CD) is a chronic relapsing intestinal inflammatory disorder that results from an abnormal mucosal immune response against intestinal bacteria in genetically susceptible individuals. Several susceptibility genes have been linked to CD… Continue reading
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P141 A LONG NONCODING RNA TRANSCRIBED FROM THE CD8 LOCUS CONTROLS FUNCTIONAL DIFFERENTIATION OF CD4 T CELLS IN THE INTESTINE
CD4 T cells adapt their immune function to the local tissue environment by differentiating into various functional subsets. At steady state, regulatory CD4 T cells (Treg) and interleukin (IL)-17-producing CD4 T cells (Th17 cells) reside in the intestin… Continue reading
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P142 CONSTITUTIVELY ACTIVE MAC-1 (CD11B) AMELIORATES INFLAMMATION IN MOUSE DSS COLITIS MODEL
Mac-1 (CD11b/CD18)-is an integrin expressed on bone marrow-derived immune cells that binds ICAM-1 to regulate leukocyte adhesion and migration across the endothelium or epithelium. The role of CD11b in tumorigenesis and colitis is controversial. It has… Continue reading
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P143 HIF1A INHIBITS PRO-INFLAMMATORY CELLULAR PROGRAM IN FOXP3+ CELLS IMPLICATED IN IBD
A perplexing observation in Crohn’s disease has been the detection of increased numbers of FOXP3+ cells within the lesions, a higher proportion of FOXP3+to CD4+ cells within the mucosa of Crohn’s patients and a significantly higher gene count of FO… Continue reading
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