Daily Archives: February 8, 2019
P144 IMPAIRED IL-22 PRODUCTION BY RORγT+GROUP 3 INNATE LYMPHOID CELLS IN CROHN’S DISEASE
Interleukin (IL)-22 plays a prominent role in the regulation of epithelial barrier integrity and the promotion of tissue repair. RORγt+group 3 innate lymphoid cells (ILC3s) are known as a major source of IL-22 in the intestinal mucosa. Given the impor… Continue reading
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P145 INACTIVATION OF IRF1 CAUSES SUSCEPTIBILITY TO COLITIS-ASSOCIATED COLORECTAL CANCER
Colorectal cancer is a highly prevalent malignancy worldwide, with an increased incidence in patients diagnosed with inflammatory bowel disorders (IBD). Risk of IBD is strongly influenced by genetic factors, including the IBD5 locus (5q31), harboring t… Continue reading
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P146 NOD2 IS REQUIRED FOR RECOVERY AGAINST MYCOBIOTA-DRIVEN INTESTINAL DISEASE AND FOR GENERATION OF PROTECTIVE TYPE 1 AND 3 HOST RESPONSES
The microbiota has emerged as a critical contributor to intestinal inflammatory diseases, however most studies have focused on bacteria despite the presence of fungi. Several clinical and experimental observations have shown that the mycobiota are impo… Continue reading
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P147 NOVEL JUNCTIONAL ADHESION MOLECULE-LIKE (JAML) REGULATES NEUTROPHIL TRANSEPITHELIAL MIGRATION DURING INTESTINAL INFLAMMATION
Neutrophil (PMN) migration in the intestine is an essential component of host defense and wound repair. However, dysregulated PMN recruitment is a hallmark of chronic active inflammatory bowel disease (IBD) characterized by persistent inflammation. Dis… Continue reading
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P148 ROLE OF IL-33-DEPENDENT INNATE IMMUNE RESPONSES IN COLITIS-ASSOCIATED CANCER
IBD patients have an increased risk of developing colorectal cancer, however, the immune cells and cytokines that mediate the transition from intestinal inflammation to cancer are poorly understood. Mucosal IL-33 is increased in UC patients, in additio… Continue reading
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P149 TARGETING OF THE INTESTINAL GLYCAN SLEA INCREASES BARRIER INTEGRITY, REDUCED INFLAMMATION DURING COLITIS AND IMPROVES COLONIC MUCOSAL WOUND HEALING
Dysregulated neutrophil (PMN) trafficking into the mucosa and associated tissue damage is a pathological hallmark of numerous human diseases including inflammatory bowel disease (IBD). In addition to excessive trafficking of PMN, mucosal inflammation i… Continue reading
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P150 THE HUMAN FC GAMMA RIIA H131 POLYMORPHISM IS A NEONATAL RECEPTOR (FCRN)-DEPENDENT HIGH RESPONDER VARIANT IN INFLAMMATORY BOWEL DISEASE
Human FcγRIIa (CD32a) contains a prevalent and clinically relevant polymorphism, possessing either a histidine (H) (CD32aH)- or arginine (R) (CD32aR) at amino acid position 131. Individuals expressing the CD32aH variant have higher risk of Crohn’s d… Continue reading
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P151 THE LONG NON-CODING RNA, IFNG-AS1/NEST, IS ASSOCIATED WITH IBD AND DRIVES A PRO-INFLAMMATORY SIGNALING CASCADE
The output of genomic transcriptional activity primarily results in the production of non-coding RNA transcripts. However, their role in inflammatory bowel disease (IBD) pathophysiology has yet to be determined. Our previous work identified IFNG-AS1/Ne… Continue reading
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P152 ANALYSIS OF HUMAN COLONIC TISSUE AND PERIPHERAL BLOOD BY MASS CYTOMETRY REVEALS IMMUNE SIGNATURES DIFFERENTIATING INFLAMMATORY STATES IN UC, CD, AND CONTROLS
Intro: Inflammatory bowel disease (IBD), consisting of ulcerative colitis (UC) and Crohn’s disease (CD), leads to chronic intestinal inflammation associated with significant morbidity. The underlying mucosal dysregulation is not entirely understood… Continue reading
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P153 LOSS OF NEUTROPHIL EXTRACELLULAR TRAPS VIA PEPTIDYL ARGININE DEIMINASE-4 DEFICIENCY AGGRAVATES CITROBACTER RODENTIUM- INDUCED GUT INFLAMMATION
Citrobacter rodentium (CR) is an attaching-effacing enteropathogen which infects mice and causes intestinal inflammation. The CR infection model is appropriate for investigating host-pathogen interactions in the gut and understanding the pathogenesis o… Continue reading
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