Daily Archives: February 8, 2019

Crohn’s disease (CD) is chronic complex autoimmune condition characterized by inflammation of the gastrointestinal tract. Pediatric CD diagnosed in patients younger than 20 years of age comprises 30% of all diagnosed CD. There is significant data to … Continue reading →

The prevalence and incidence of inflammatory bowel diseases (IBD) has rapidly increased over the past century. Although the etiology of IBD remains unclear, changes in societal norms, environment, diet, and lifestyles are likely contributory factors th… Continue reading →

Background and Objectives: Recent evidence suggests that intestinal fungal communities possess Immunomodulatory properties and can influence the development of intestinal inflammation. Serum antibodies against the Saccharomyces cerevisiae mannan (AS… Continue reading →

Adherent and invasive Escherichia coli (AIEC) appear to expand during inflammation and are observed in the ileal mucosa in subsets of Crohn’s patients. However, AIEC pathogenesis is poorly understood and cause-effect relationships between AIEC and IB… Continue reading →

Despite great advancements in therapy, it remains unclear why inflammation in the digestive system of patients suffering Crohn’s Disease (CD) is progressive and leads to complications (e.g., enteric fistulas) that are only alleviated by surgical remo… Continue reading →

The influence of genomics, immune response, and environment on inflammatory bowel disease (IBD) varies among patients. We aimed to characterize the differences and determine age and disease effects on the gut microbiome across the pediatric age range, … Continue reading →

Infections (candidiasis) caused by Candida spp. including C. tropicalis, have dramatically increased worldwide, indicating that this organism is an emerging pathogenic yeast. Our recent studies indicate that C. tropicalis is significantly higher in C… Continue reading →

Patients with inflammatory bowel disease (IBD) have altered intestinal microbial composition, but whether this altered microbiota is a cause or consequence of inflammation is unclear. The importance of the gut microbiota in IBD pathogenesis has been sh… Continue reading →

Patients with Crohn’s disease (CD) suffer from abnormally high rates of depression and anxiety. Depression among patients with CD are higher than other debilitating chronic medical conditions, such as cancer. Behavioral co-morbidities are associated … Continue reading →

Although inflammatory bowel diseases (IBD) is presumed to develop as the result of dysregulated immune response to the intestinal microbiota in genetically susceptible hosts, the association between microbiota and genotypes in IBD patients remains uncl… Continue reading →