Daily Archives: February 8, 2019

Several studies have indicated that home infusions of biologic agents are safe for selected patients with inflammatory bowel disease. Vedolizumab is a monoclonal antibody directed against the α4β7 integrin and is indicated for the treatment of modera… Continue reading →

DEVELOP is a multicenter, prospective, observational registry of the long-term safety and clinical outcomes of 6070 pediatric patients with inflammatory bowel disease (IBD; Crohn’s disease, ulcerative colitis, or indeterminate colitis) treated with a… Continue reading →

There have been uptrending rates of Herpes Zoster (HZ) in the U.S. in recent years, with an estimated lifetime incidence of 1 in 3 individuals in the general population. Patients with inflammatory bowel disease (IBD), especially those on immunosuppress… Continue reading →

Crohn’s disease (CD) is an inflammatory disorder of unclear etiology that may involve the entire gastrointestinal tract from mouth to the perianal area and may be associated with several extraintestinal manifestations. Venous thromboembolic events re… Continue reading →

Extraintestinal manifestations (EIMs) represent symptoms outside the gastrointestinal tract and frequently occur among patients with ulcerative colitis (UC). The aim of the current study was to estimate the prevalence of EIMs in UC patients initiating … Continue reading →

The association between inflammatory bowel disease (IBD) and colorectal cancer is well-known. However, the relationship between IBD and other malignancies has been less clearly defined in the literature to date. The objective of this study was to evalu… Continue reading →

Crohn’s disease (CD) commonly causes perianal fistulas (PF), which are difficult and costly to treat. With 10% having PF present at CD diagnosis, delay in diagnosis is associated with worse outcomes. Furthermore, >20% develop PF later, with few reliable predictors, and preventive strategies are nonexistent. We sought to characterize the variation in CD diagnosis to identify potential predictors of PF development. We hypothesize that timely diagnosis and treatment is associated with lower rate of PF development. Continue reading →

Some physicians have concern that radiation treatment for prostate cancer may precipitate flares or complications in patients with inflammatory bowel disease (IBD). However, controversy remains due to limited data in regard to the best treatment approa… Continue reading →

Patients with inflammatory bowel disease (IBD) are at significantly increased risk for Clostridium difficile infection (CDI). CDI in IBD is associated with increased in-hospital mortality, IBD treatment failure, re-hospitalization and high CDI recurren… Continue reading →

Objectives: Pediatric patients with inflammatory bowel disease (IBD) are at increased risk of venous thromboembolism (VTE), but are often overlooked for pharmacologic prophylaxis. We instituted a risk-stratification algorithm to identify high-risk pa… Continue reading →