Daily Archives: February 12, 2019
Organ Failure due to Systemic Injury in Acute Pancreatitis
Acute pancreatitis may be associated with both local and systemic complications. Systemic injury manifests in the form of organ failure which is seen in approximately 20% of all cases of acute pancreatitis and defines ‘severe acute pancreatitis’. O… Continue reading
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The role of the microbiome in immunologic development and its implication for pancreatic cancer immunotherapy
Our understanding of the microbiome and its role in immunity, cancer initiation, and cancer progression has evolved significantly over the past century. The “germ theory of cancer” was first proposed in the early 20th century, and shortly thereafte… Continue reading
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Mutations in Hepatitis D Virus Allow it to Escape Detection by CD8+ T Cells and Evolve at the Population Level
Hepatitis D virus (HDV) super-infection in patients with hepatitis B virus (HBV) is associated with rapid progression to liver cirrhosis and hepatocellular carcinoma. Treatment options are limited, and no vaccine is available. Although HDV-specific CD8… Continue reading
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Democratizing endoscopic submucosal dissection: Single-operator fully robotic colorectal ESD in a pig model
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Systems Biology Analyses Reveal Hyperactivation of Transforming Growth Factor beta and JNK Signaling pathways in Esophageal Cancer
Esophageal adenocarcinoma (EAC) is resistant to standard chemoradiation treatments and few targeted therapies are available. We used large-scale tissue profiling and pharmacogenetic analyses to identify deregulated signaling pathways in EAC tissues tha… Continue reading
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