Goblet cells (GC) contribute critically to intestinal barrier function and mucosal immune homeostasis. GC dysfunction is linked to human inflammatory bowel disease (IBD). However, the cellular mechanisms that regulate GC function are incompletely understood. Using a novel mouse model generated in our lab, we have recently identified that an important regulatory subunit of the BK-type potassium channel, called LRRC26 (leucine-rich-repeat containing protein 26), specifically localizes to intestinal GCs.