Background and Objectives: Recent evidence suggests that intestinal fungal communities possess Immunomodulatory properties and can influence the development of intestinal inflammation. Serum antibodies against the Saccharomyces cerevisiae mannan (ASCA) are a common hallmark of Crohn’s Disease (CD) and can develop in response to intestinal fungi. Despite the identification of few molecules involved in the recognition and immunity to intestinal fungi, the cell subsets that initiate and regulate mucosal immune responses to the mycobiota remain unknown.