Ileocolic resection (ICR) is the most common surgical procedure for Crohn’s disease (CD). Reconstruction is most commonly achieved with stapled side-to-side (SSTS) or hand-sewn (HS) ileocolic anastomosis (ICA), depending on tissue quality, surgeon experience, and surgeon preference. We aimed to compare short-term complications and long-term recurrence-free survival of CD between patients who underwent SSTS vs.HS anastomoses in our institution.