Ileocolic resection (ICR) is the most common surgical procedure for Crohn’s disease (CD). Anastomotic construction is most commonly achieved with stapled side-to-side (SSTS) or hand-sewn end-to-end anastomosis (ETE), with the decision often made by tissue quality, surgeon experience, and surgeon preference. Another option that combines advantages of both SSTS and ETE, and which is extensively used at our institution, is the Stapled End-to-Side anastomosis (SETS). SETS recapitulates the normal anatomy with the ileum entering the colon at a right angle, and facilitates reconstruction in the face of a lumen size discrepancy between colon and ileum.