Dysregulated neutrophil (PMN) trafficking into the mucosa and associated tissue damage is a pathological hallmark of numerous human diseases including inflammatory bowel disease (IBD). In addition to excessive trafficking of PMN, mucosal inflammation is also associated with specific alterations in cellular glycosylation. Glycans represent highly accessible binding epitopes that decorate key epithelial and PMN glycoproteins involved in the regulation of PMN transepithelial migration (TEpM) and epithelial function.