Monthly Archives: February 2019
04 DIAGNOSTIC ACCURACY OF THE SERUM-BASED MUCOSAL HEALING INDEX ASSAY IN CROHN’S DISEASE AND COMPARATIVE ACCURACY TO FECAL CALPROTECTIN IN ROUTINE PRACTICE
Biomarker-based management improves outcomes in Crohn’s disease (CD) compared to symptoms alone, but existing biomarkers have limitations. We assessed the diagnostic performance of the Mucosal Healing Index (MHI; PROMETHEUS MonitrTM) for detecting mu… Continue reading
P028 A BLOOD-BASED PROGNOSTIC BIOMARKER IN INFLAMMATORY BOWEL DISEASE; TOWARDS PERSONALISED MEDICINE IN IBD
The course of Inflammatory Bowel Disease (IBD incorporating both Crohn’s Disease and ulcerative colitis) varies substantially between affected individuals, but reliable prognostic markers are not available in clinical practice. This hinders disease m… Continue reading
P029 ACCURACY OF FECAL CALPROTECTIN IN DETECTING SMALL BOWEL CROHN’S DISEASE: A META-ANALYSIS AND SYSTEMATIC REVIEW
Identifying active small bowel Crohn’s Disease (CD) is often challenging due various reasons. The location of Crohn’s disease and often the disease process itself make direct visualization difficult. Fecal calprotectin (FCP) is a well-established m… Continue reading
P030 DELAYED DIAGNOSIS OF CROHN’S DISEASE IS COMMON AND ASSOCIATED WITH AN INCREASED RISK OF DISEASE COMPLICATIONS
There is increasing emphasis on early diagnosis and intervention in inflammatory bowel disease (IBD), in particular Crohn’s disease (CD). Early treatment with effective medications can prevent IBD progression towards complications, surgery and disabi… Continue reading
P031 DETECTION OF BACTERIAL ENTERIC INFECTION IMPACTS MANAGEMENT OF OUTPATIENTS WITH FLARES OF INFLAMMATORY BOWEL DISEASE
Multiplex polymerase chain reaction based stool assays for gastrointestinal pathogens (GI PCR) allow for the timely and accurate detection of enteric infections that were poorly characterized by conventional means such as stool culture. Despite the in… Continue reading
P032 NONINVASIVE BIOMARKERS FOR INFLAMMATORY BOWEL DISEASE MONITORING: DRAWBACKS AND POTENTIAL
Approximately 1.6 million Americans suffer from inflammatory bowel diseases (IBD); Ulcerative colitis (UC) and Crohn’s disease (CD). The goal of IBD therapy is to induce deep remission characterized by resolution of both endoscopic and histologic abn… Continue reading
P033 EFFICACY OF MIRIKIZUMAB ON HEALTH-RELATED QUALITY OF LIFE IN PATIENTS WITH ULCERATIVE COLITIS: A RANDOMISED, DOUBLE-BLIND, CONTROLLED, PHASE 2 STUDY
The efficacy and safety of mirikizumab (miri), an IL-23p19 antibody, has been evaluated in moderate-to-severe ulcerative colitis (UC) in a phase 2, randomized, double-blind, placebo (pbo)-controlled trial (AMAC, NCT02589665; presented at DDW 2018). Mir… Continue reading
P034 EFFICACY OF USTEKINUMAB IN CROHN’S DISEASE AT MAINTENENCE WEEK 56: IM-UNITI STUDY
Ustekinumab (UST) is a human IgG1κ monoclonal antibody that binds to the p40 protein subunit, which is common to both IL-12 & IL-23 cytokines. It is approved for use in treatment of moderately to severely active Crohn’s disease (CD). The primary endpoint data (Wk 44) from the pivotal Phase 3 study, IM-UNITI, has been previously reported. We examined efficacy of UST after 1 year of maintenance therapy (Wk 56). Continue reading
P035 ETROLIZUMAB TREATMENT MODULATES SOLUBLE MADCAM-1 LEVELS IN SERUM IN PATIENTS WITH CROHN’S DISEASE
Etrolizumab, a monoclonal antibody to the β7 integrin, inhibits both α4β7:mucosal addressin cell adhesion molecule 1 (MAdCAM-1)–mediated lymphocyte trafficking to the gut mucosa and αEβ7:E-cadherin–mediated lymphocyte retention. In patients wi… Continue reading
P036 LONG-TERM SAFETY AND EFFICACY OF THE ANTI-MUCOSAL ADDRESSIN CELL ADHESION MOLECULE-1 (MADCAM-1) ANTIBODY SHP647 IN ULCERATIVE COLITIS: AN OPEN-LABEL EXTENSION STUDY (TURANDOT II)
SHP647, a fully human IgG2 monoclonal antibody, binds to human mucosal addressin cell adhesion molecule-1 (MAdCAM-1) to reduce lymphocyte homing to the gastrointestinal tract. SHP647 was well tolerated in a randomized, double-blind phase 2 trial (TURAN… Continue reading