Monthly Archives: February 2019

Objectives: Endoscopic severity of ulcerative colitis predicts clinical outcomes, making it critical for assessing efficacy of new therapies. However, its use in routine practice is limited by availability of experienced and trained human reviewers. … Continue reading →

Most patients with Crohn’s disease (CD) that undergo intestinal resection will subsequently experience disease recurrence. Endoscopic recurrence (ER) after intestinal resection for CD precedes the clinical recurrence, and its severity correlates with… Continue reading →

We reported a novel 1-day colon capsule endoscopy (CCE) regimen with high completion rate and good acceptability especially in clinically inactive cases and therefore suggested its potential utility as a non-invasive monitoring tool to evaluate mucosal… Continue reading →

The current gold standard for monitoring the severity and treatment of ulcerative colitis is a combination of endoscopy mucosal scores with concomitant pathology scores. The Pediatric Ulcerative Colitis Assessment Index (PUCAI) was developed as an easy… Continue reading →

Dysmenorrhea and ulcerative colitis (UC) are conditions that commonly affect women of reproductive age. Despite their similar symptoms, the relationship between the two is poorly understood. The aims of this study were to explore the relationships betw… Continue reading →

Histologic remission is a potentially valuable means of assessing disease activity and treatment response in ulcerative colitis (UC). However, the efficacy of existing therapies to achieve this outcome is unclear. We performed a systematic review and m… Continue reading →

Anti-tumor necrosis factor (anti-TNF) agents are widely used in the treatment of moderate to severe ulcerative colitis (UC) since commercial approval in 1998. Many patients however ultimately require surgery with ileal pouch-anal anastomosis (IPAA). Co… Continue reading →

Mucosal healing is widely recognized as the gold standard for assessing Crohn’s disease (CD) activity. Existing indices for assessing mucosal healing such as the simple endoscopic score for CD (SES-CD) are cumbersome and not commonly used in practice… Continue reading →

The most common complication following a proctocolectomy with ileal pouch-anal anastomosis (IPAA) is the development of pouchitis, however gaps exist in our understanding of the clinical course of pouch-related disorders. We used data from a cohort of … Continue reading →

Patients with Crohn’s disease (CD) have increased risk of developing colorectal cancer (CRC) compared with the background population. In our previous study, CRC associated with CD in Japan mostly arises in anorectal region, while colonic cancer is pr… Continue reading →