Monthly Archives: February 2019

The incidence and prevalence of ulcerative colitis (UC) and Crohn’s disease (CD) is stabilizing in the Western world, but increasing in developing countries. However, epidemiological data on IBD is lacking from Latin American countries. The aim of th… Continue reading →

As the focus shifts to precision medicine, there is increasing prioritization of intervening before disease inception and early intervention as these will allow for disease prevention and/or prompt treatment with therapies with improved side-effect pro… Continue reading →

Inflammatory Bowel Disease (IBD), characterized by chronic inflammation of the intestine, is propelled by alterations in the immune profile and inflammatory mediators within affected tissue. However, as IBD pathobiology is heterogeneous in nature, a mo… Continue reading →

Inflammatory bowel diseases (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), comprise a group of immune disorders of the digestive tract with significant negative impacts on quality of life. The etiologies are not well understood, b… Continue reading →

Crohn’s disease (CD) is a relapsing-remitting inflammatory disorder with flares of inflammation. We have recently shown that CD associated DNA methylation signatures in blood are a transient consequence of inflammation. Here, we investigated how gene… Continue reading →

Oncostatin M (OSM) and OSM receptor (OSMR) were found to be highly expressed in inflamed intestinal tissue in patients with Crohn’s disease (CD) and ulcerative colitis (UC).1 West et al. also found elevations of mucosal OSM was strongly associated w… Continue reading →

The recruitment of lymphocytes from the circulation to the gut mucosa plays a critical role in inflammatory bowel disease (IBD); in particular, most classes of T cells promote disease; however regulatory T cells (Treg) suppress immune responses and res… Continue reading →

We have previously shown that neutralization of IL-1α with a specific murine monoclonal antibody (FLO1) in 25-wk old SAMP1/YitFc (SAMP) mice with established CD-like ileitis, ameliorates ileitis severity. These results were associated with gut microbi… Continue reading →

It is well-established that microbiota and immune cells signal to colon epithelial cells to increase production of chemokines and pro-inflammatory cytokines that can accelerate inflammation, but we have found that TGFβ/SMAD4 signaling in colon epithel… Continue reading →

The complex inflammatory bowel diseases, Crohn’s Disease (CD) and Ulcerative Colitis (UC), are driven by a myriad of immune, microbial, and environmental factors that manifest in tissue inflammation and lesions. Though several mouse models exist for … Continue reading →