Monthly Archives: February 2019
P114 MCH LINKS IMMUNOMETABOLSIM TO INTESTINAL INFLAMMATION
Melanin concentrating hormone (MCH) was first identified as a hypothalamic neuropeptide regulating feeding behavior and energy balance. The MCH receptor, MCHR1, is present in brain as well as in several peripheral tissues including the gastrointestinal… Continue reading
P115 SPECIFIC CYTOKINE PROFILES TO IDENTIFY RESPONSE TO ANTI TUMOR NECROSIS FACTOR α BIOLOGICAL THERAPY IN INFLAMMATORY BOWEL DISEASE
biological therapies such as anti tumor necrosis factor α (TNFα) drug infliximab (IFX), have led to substantial improvements in the treatment of Crohn’s disease (CD) patients. However, approximately a third of them do not have a response during ind… Continue reading
14 AUTOPHAGY PROTEIN ATG16L1 PREVENTS NECROPTOSIS IN THE INTESTINAL EPITHELIUM
Previous studies revealed both genetic and environmental factors contribute to the Crohn’s disease pathogenesis. ATG16L1, an essential component of autophagy, is one of the susceptibility genes of the disease. We previously showed that mice with decr… Continue reading
08 IL-17A REGULATES INTESTINAL EPITHELIAL CELLS REGENERATION VIA ATONAL HOMOLOG (ATOH)1
IL-17A, derived from Th17 cells, plays an important role in intestinal host defense. However, the interaction and potential molecular synergies between IL-17A and epithelial cell lineages, intestinal stem cells (ISCs), and progenitors of the intestine … Continue reading
P116 PERIOSTIN PROMOTES ENDOPLASMIC RETICULUM STRESS-MEDIATED FIBROSIS IN CROHN’S DISEASE
Fibrostenosis complicates Crohn’s disease in the 30-50% of patients with a Montreal B2 phenotype. Current medical therapies can delay but no prevent critical fibrostenosis and the need for surgery. Transforming growth factor-β1 (TGF-β1)-induced exc… Continue reading
P117 PLATELET ACTIVATING FACTOR AND TNFα HAVE SYNERGISTIC EFFECTS IN PROMOTING INTESTINAL EPITHELIAL MIGRATION AND MUCOSAL WOUND REPAIR
Epithelial cells migrate and proliferate to cover denuded mucosal surfaces. The intestinal mucosal infiltrating immune cells and epithelium secrete an array of inflammatory mediators that have been proposed to modulate wound repair. Here, we report tha… Continue reading
P118 TARGETING ENDOPLASMIC RETICULUM STRESS FOR THE TREATMENT OF FIBROSIS IN CROHN’S DISEASE
Progressive tissue remodeling characterized by extensive collagen production and excess extracellular matrix deposition leads to intestinal fibrosis and stricture formation in patients with fibrostenotic Crohn’s disease. Currently medical therapies c… Continue reading
P119 THE ROLE OF PTPN2 SNP IN THE PATHOGENESIS OF FIBROSIS IN CROHN’S DISEASE
Genome-wide association studies (GWAS) have identified >200 risk loci in Crohn’s disease and ulcerative colitis or as shared loci. Pathway analysis of these risk loci identified several variants in the Jak-STAT candidate network and of protein tyrosine phosphatase non-receptor type 2 (PTPN2, TC-PTP). PTPN2 dephosphorylates not only receptor protein tyrosine kinases but also non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, the Src family kinases, STAT3. In subepithelial myofibroblasts from strictured ileum of patient with fibrostenotic Crohn’s disease we identified a unique signaling pathway, of JAK-mediated STAT3(S727) and STAT3(Y705) phosphorylation regulated increased TGF-β1 expression and increased collagen I production. Continue reading
P120 BBT-401 IS A SELECTIVE PELLINO-1 PROTEIN-PROTEIN INTERACTION INHIBITOR IN CLINICAL DEVELOPMENT TARGETING A FIRST-IN-CLASS DRUG FOR UC TREATMENT
Toll-like receptor (TLR) pathways play a pivotal role during the pathogenesis of inflammatory diseases including ulcerative colitis (UC) by recognizing pathogen-associated molecular patterns and consequently inducing proinflammatory signals. Pellino-1 … Continue reading
P121 MAST CELLS AND EOSINOPHILS IN GASTRODUODENUAL MUCOSA OF CHILDREN WITH CROHN’S DISEASE
A few studies have reported increased numbers of mast cells (MC) in intestinal mucosa of patients with Crohn’s disease (CD). Also, several studies have established that eosinophils are increased in colonic mucosa of adults; however, the distribution … Continue reading