Monthly Archives: February 2019
P127 THE TRANS-GOLGI NETWORK PROTEIN AFTIPHILIN REGULATES COLONIC EPITHELIAL CELL MIGRATION AND IS CRUCIAL TO EMBRYONIC DEVELOPMENT
Colonic epithelium forms a selective barrier between lumen and colonic mucosa. The integrity of colonic epithelium is maintained by cell proliferation, migration and expression of cellular junctions. A compromised colonic epithelium contributes to colo… Continue reading
P128 INHIBITION OF INTESTINAL EPITHELIAL CELL PYROPTOSIS AND ASSOCIATED MUCOSAL BARRIER DEFECTS IS A POTENTIAL THERAPEUTIC MECHANISM OF ACTION FOR MESALAMINE IN IBD
Mucosal barrier dysfunction to luminal microbes plays a crucial role in the development of intestinal inflammation in inflammatory bowel disease (IBD). Recently, intestinal epithelial cell (IEC) death resulting from a form of innate immune activation c… Continue reading
P129 INTESTINAL EPITHELIAL CELL-SECRETED EXTRACELLULAR VESICLES PROMOTE THE FUNCTION OF LACTOBACILLUS RHAMNOSUS GG AGAINST INTESTINAL INFLAMMATION
Although the composition of the gut microbiota has been shown to be influenced by host genetics and environmental factors, the effects of the host on the functions of microbial communities remain poorly understood. Intestinal epithelial cells (IECs) ex… Continue reading
28 MESENTERIC TERTIARY LYMPHOID ORGANS INTEGRATED INTO THE INTESTINAL-DRAINING LYMPHATIC NETWORK ARE RESISTENT TO ANTI-TNF THERAPHY IN CROHN’S DISEASE MOUSE MODEL
Characterization of Crohn’s disease (CD) includes susceptible mucosal surfaces via abnormal intestinal permeability caused by either deregulated interactions between the bacterial flora and surface epithelial cells or an overwhelming host immune resp… Continue reading
29 HUMAN BONE MARROW DERIVED MESENCHYMAL STEM CELLS MEDIATE IMMUNOSUPPRESSION IN EXPERIMENTAL CROHN’S DISEASE BY SECRETING PROSTAGLANDIN E2 AND REPROGRAMMING MACROPHAGES TO AN ANTI-INFLAMMATORY PHENOTYPE
Locally injected mesenchymal stem cells (MSCs) are now an approved therapy in European Union for perianal Crohn’s disease (CD) fistulas, however, clinical studies have shown limited efficacy of systemic MSC therapy for luminal CD. Thus, we studied th… Continue reading
P130 BIOTIN SUPPLEMENTATION AMELIORATES MURINE COLITIS BY MAINTAINING INTESTINAL MUCOSAL INTEGRITY
Biotin deficiency is often overlooked in patients with Inflammatory Bowel Disease, but it may have profound implications in the GI tract. Biotin is a water-soluble vitamin that must be obtained from exogenous sources and is involved in the metabolism o… Continue reading
P131 CHARACTERIZING THE MICROBIOTA-GUT-BRAIN AXIS IN A MURINE MODEL OF PEDIATRIC INFLAMMATORY BOWEL DISEASE
Inflammatory bowel diseases (IBD) are chronic intestinal diseases affecting over 1.4 million Americans. Children and adolescents typically have more severe disease and are more likely to display extra-intestinal effects, including psychosocial deficits… Continue reading
P132 DEXTRAN SULFATE SODIUM-INDUCED COLITIS IS ATTENUATED IN TRACE AMINE ASSOCIATED RECEPTOR 1 KNOCKOUT MICE
Advances in studying the onset and progression of ulcerative colitis (UC) suggest that both diet and microbiome play a critical role in the progression of disease, though no causal link has been found. Lactobacillus species found in the microbiome prod… Continue reading
P135 ORALLY ADMINISTERED FOLH1/GCPII INHIBITORS AS NOVEL THERAPEUTICS IN INFLAMMATORY BOWEL DISEASE (IBD)
The folate hydrolase gene (FOLH1), which encodes for the enzyme glutamate carboxypeptidase II (GCPII), has been implicated in the pathogenesis of inflammatory bowel disease (IBD) where it exhibits a robust 300-1000% increase in enzymatic activity in in… Continue reading
P136 ELTANEXOR, AN EXPORTIN-1 INHIBITOR, RAPIDLY DECREASES INFLAMMATION AND IMPROVES OUTCOMES IN VITRO AND IN A DSS MODEL OF IBD
Crohn’s disease and ulcerative colitis are inflammatory bowel diseases (IBD) leading to abdominal pain, severe diarrhea, fatigue and weight loss. Over 3.5 million Americans and Europeans are estimated to have IBD, yet there is currently no cure, maki… Continue reading