Monthly Archives: February 2019
Blood-derived DNA Methylation Signatures of Crohn’s Disease and Severity of Intestinal Inflammation
Crohn’s disease is a relapsing and remitting inflammatory disorder with a variable clinical course. Although most patients present with an inflammatory phenotype (B1), approximately 20% of patients rapidly progresses to complicated disease, which inc… Continue reading
Early intra-acinar events in Pathogenesis of Pancreatitis
Premature activation of digestive enzymes in the pancreas has been linked to development of pancreatitis for more than a century. Recent development of novel models to study the role of pathologic enzyme activation has led to advances in our understand… Continue reading
Current concepts in severe acute and necrotizing pancreatitis: an evidence-based approach
The incidence of acute pancreatitis continues to rise, inducing substantial medical and social burden, with annual costs exceeding two billion dollars in the USA alone. Although the majority of patients develop mild pancreatitis, 20% develop severe and… Continue reading