Monthly Archives: March 2019
Don’t be a time change zombie
Banking up on sleep ahead of the March 10 time change when clocks spring forward an hour is a smart way to avoid the frantic feelings and lingering fatigue associated with daylight saving time — if you do it the right way. Continue reading
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Kevin Hartley was an organ donor, and his mother had one wish: to hear her son’s heartbeat one more time. She got the chance.
As her 21-year-old son Kevin lay dying in a hospital bed, Wendy Hartley asked her daughter, Amber, to find a stethoscope. She wanted to listen to his heartbeat once more before he passed. Nearly two years after his death, she heard his heartbeat again … Continue reading
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HCV-induced Epigenetic Changes Associated With Liver Cancer Risk Persist After Sustained Virologic Response
Epigenetic reprogramming drives HCV liver cancer risk following DAA cure. Continue reading
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GNAI1 and GNAI3 Reduce Colitis-Associated Tumorigenesis in Mice by Blocking IL6 Signaling and Downregulating Expression of GNAI2
Interleukin 6 (IL6) and tumor necrosis factor (TNF) contribute to the development of colitis-associated cancer (CAC). We investigated these signaling pathways and the involvement of G protein subunit alpha i1 (GNAI1), GNAI2, and GNAI3 in the developmen… Continue reading
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Association Between Antibiotics in the First Year of Life and Celiac Disease
The intestinal microbiota is thought to be involved in pathogenesis of celiac disease, along with genetic variants and dietary gluten. The gut microbiota is strongly influenced by systemic antibiotics—especially in early life. We explored the associa… Continue reading
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Real-time Targeted Genome Profile Analysis of Pancreatic Ductal Adenocarcinomas Identifies Genetic Alterations that Might be Targeted with Existing Drugs or Used as Biomarkers
It has been a challenge to select treatment for patients with pancreatic ductal adenocarcinomas (PDACs) based on genome alterations. We performed targeted genomic profile analyses of a large number of PDACs to assess the full spectrum of actionable gen… Continue reading
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Not your typical inflammatory bowel disease flare: diarrhea and weight loss masquerading as recrudescence of ulcerative colitis
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Gastric Parietal Cell Physiology And Helicobacter Pylori-Induced Disease
Acidification of the gastric lumen poses a barrier to transit of potentially pathogenic bacteria and enables activation of pepsin to complement nutrient proteolysis initiated by salivary proteases. Histamine-induced activation of the protein kinase A s… Continue reading
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