Monthly Archives: March 2019
Gut Microbes Drive T-Cell Infiltration into Colorectal Cancers And Influence Prognosis
Cremonesi E, Governa V, Garzon JFG, et al. Gut microbiota modulate T cell trafficking into human colorectal cancer Gut 2018;67:1984–1994. Continue reading
Metabolic Alterations as a Signpost to Early Pancreatic Cancer
Pancreatic cancer is a terrible disease. Patients often become seriously ill within months of diagnosis and <10% of patients are cured of their cancer. To make matters worse, the number of cases of pancreatic cancer continues to increase each year, and it will soon become the second leading cause of cancer death in the United States.1 Thus, even in a time of hyperbole, one can reasonably say that dealing with pancreatic cancer is a matter of great urgency if we are to continue progress in reducing cancer-related mortality. Continue reading
How Deep Are the Roots of Barrett’s Esophagus?
Owen RP, White MJ, Severson DT, et al. Single cell RNA-seq reveals profound transcriptional similarity between Barrett’s oesophagus and oesophageal submucosal glands. Nature Comms 2018;9:4261–4272. Continue reading
Lights and Shadows on Fibrates as Second-Line Therapy of Primary Biliary Cholangitis
Corpechot C, Chazouillères O, Rousseau A, et al. A placebo-controlled trial of bezafibrate in primary biliary cholangitis. N Engl J Med 2018;378:2171–2181. Continue reading
Making the Stomach Pump Better: The Answer for Gastroparesis?
“Everything should be made as simple as possible, but not simpler.“—Albert Einstein Continue reading
Efficacy of Budesonide Orodispersible Tablets as Induction Therapy for Eosinophilic Esophagitis in a Randomized Placebo-controlled Trial
Swallowed topical-acting corticosteroids are recommended as first-line therapy for eosinophilic esophagitis (EoE). Asthma medications not optimized for esophageal delivery are sometimes effective, although given off label. We performed a randomized, pl… Continue reading
Correction
Peery AF, Crockett SD, Murphy CC, et al. Burden and cost of gastrointestinal, liver, and pancreatic diseases in the United States: update 2018. Gastroenterology 2019 Jan;156:254-272.e11 Continue reading
Tomorrow’s information sessions can help you prepare for retirement
Representatives from Fidelity Investments, the company that manages VUMC’s retirement savings plan, and a Medicare specialist will host on-campus retirement planning workshops tomorrow. Continue reading