Daily Archives: April 15, 2019
Model to Calculate Harms and Benefits of Early vs Delayed Liver Transplantation for Patients with Alcohol-Associated Hepatitis
Early liver transplantation (without requiring a minimum period of sobriety) for severe alcohol-associated hepatitis (AH) is controversial—many centers delay eligibility until a specific period of sobriety (such as 6 months) has been achieved. To inf… Continue reading
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Narrow-band Imaging for Detection of Neoplasia at Colonoscopy: a Meta-analysis of Data From Individual Patients in Randomized Controlled Trials
Adenoma detection rate (ADR) is an important quality assurance measure for colonoscopy. Some studies suggest that narrow band imaging (NBI) may be more effective at detection of adenomas than white-light endoscopy (WLE) when bowel preparation is optima… Continue reading
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Methylation Tolerance-based Functional Assay to Assess Variants of Unknown Significance in the MLH1 and MSH2 Genes and Identify Patients With Lynch Syndrome
Approximately 75% of patients with suspected Lynch syndrome carry variants in MLH1 or MSH2—proteins encoded by these genes are required for DNA mismatch repair (MMR). However, 30% of these are variants of unknown significance (VUS). A assay that meas… Continue reading
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Reconciliation of Recent Helicobacter pylori Treatment Guidelines in a Time of Increasing Resistance to Antibiotics
Increasing resistance to antibiotics, worldwide, has adverse effects on the effectiveness of standard therapies to eradicate Helicobacter pylori infection. We reviewed guidelines developed by expert groups in Europe, Canada, and the United States for t… Continue reading
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High-fat Diet Accelerates Carcinogenesis in a Mouse Model of Barrett’s Esophagus via IL8 and Alterations to the Gut Microbiome
Barrett’s esophagus (BE) is a precursor to esophageal adenocarcinoma (EAC). Progression from BE to cancer is associated with obesity, possibly due to increased abdominal pressure and gastroesophageal reflux disease, although this pathogenic mechanism… Continue reading
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“My Southern Health”: One family’s story: the price of distracted driving
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Registration open for “Addressing the Burnout Epidemic” training program, July 9-12
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VUMC Baby Shower for new and expectant parents is May 13
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Next Bedside Matters rounds is tomorrow
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VUMC in the news
A roundup of a few recent stories from the press about Vanderbilt University Medical Center. Continue reading
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