Daily Archives: April 26, 2019
Depression, Antidepressants, and Inflammatory Bowel Disease: Implications for Future Models of Care
Frolkis AD, Vallerand IA, Shaheen A-A, et al. Depression increases the risk of inflammatory bowel disease, which may be mitigated by the use of antidepressants in the treatment of depression. Gut 2018;doi:10.1136/gutjnl-2018-317182 Continue reading
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Noninvasively Predicting Hemodynamic Response to Carvedilol in Cirrhotic Patients with Varices: You Have Some Ex-Spleening to Do
Kim HY, So YH, Kim W, et al. Noninvasive response prediction in prophylactic carvedilol therapy for cirrhotic patients with esophageal varices. J Hepatol 2019;70:412–422. Continue reading
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Indelibly Stamped by Hepatitis C Virus Infection: Persistent Epigenetic Signatures Increasing Liver Cancer Risk
Chronic hepatitis C virus (HCV) infections affect an estimated 71 million individuals worldwide. The virus establishes persistence in about 70% of cases and, in the majority, infections remain asymptomatic. However, persistent HCV infection causes prof… Continue reading
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Effectiveness of Infliximab Biosimilar in Crohn’s Disease: A Dime, A Dozen
Meyer A, Rudant J, Drouin J, et al. Effectiveness and safety of reference infliximab and biosimilar in Crohn disease: a French equivalence study. Ann Intern Med 2019;170:99–107. Continue reading
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Confirming Complexity: Assessing Environmental and Genetic Risk Factors for Inflammatory Bowel Disease
The incidence of inflammatory bowel disease (IBD) is increasing worldwide with the highest incidence rates in westernized countries such as those of northern Europe, the United Kingdom, and North America. These countries share many possible environment… Continue reading
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The Present State and Future Direction of Regenerative Medicine for Perianal Crohn’s Disease
Perianal Crohn’s disease (CD), affecting nearly one-third of patients with CD, is a highly morbid condition owing to incontinence, perianal pain, recurrent infection, and decreased quality of life.1 Notoriously difficult to treat, patients are left c… Continue reading
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Techniques and Technologies for Increasing Adenoma Detection at Colonoscopy: Seeing More With Blue
Detection of adenomas is central to the effectiveness of colonoscopy for colorectal cancer prevention.1 Yet variation in adenoma detection between endoscopists is substantial and translates into variation in cancer protection between endoscopists.2 Res… Continue reading
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