Monthly Archives: April 2019
CME Exam 3: Real-time Targeted Genome Profile Analysis of Pancreatic Ductal Adenocarcinomas Identifies Genetic Alterations that Might be Targeted with Existing Drugs or Used as Biomarkers
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CME Exam 1: Zenker’s Diverticulum Per-Oral Endoscopic Myotomy Techniques: Changing Paradigms
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CME Exam 2: Events Within the First Year of Life, But Not the Neonatal Period, Affect Risk for Later Development of Inflammatory Bowel Diseases
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We thank Rayar et al and Moro et al, for their interest in our recent publication1 and for highlighting some challenging issues regarding primary biliary cholangitis (PBC) recurrence after liver transplantation (LT). Continue reading
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Depression, Antidepressants, and Inflammatory Bowel Disease: Implications for Future Models of Care
Frolkis AD, Vallerand IA, Shaheen A-A, et al. Depression increases the risk of inflammatory bowel disease, which may be mitigated by the use of antidepressants in the treatment of depression. Gut 2018;doi:10.1136/gutjnl-2018-317182 Continue reading
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Noninvasively Predicting Hemodynamic Response to Carvedilol in Cirrhotic Patients with Varices: You Have Some Ex-Spleening to Do
Kim HY, So YH, Kim W, et al. Noninvasive response prediction in prophylactic carvedilol therapy for cirrhotic patients with esophageal varices. J Hepatol 2019;70:412–422. Continue reading
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Indelibly Stamped by Hepatitis C Virus Infection: Persistent Epigenetic Signatures Increasing Liver Cancer Risk
Chronic hepatitis C virus (HCV) infections affect an estimated 71 million individuals worldwide. The virus establishes persistence in about 70% of cases and, in the majority, infections remain asymptomatic. However, persistent HCV infection causes prof… Continue reading
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Effectiveness of Infliximab Biosimilar in Crohn’s Disease: A Dime, A Dozen
Meyer A, Rudant J, Drouin J, et al. Effectiveness and safety of reference infliximab and biosimilar in Crohn disease: a French equivalence study. Ann Intern Med 2019;170:99–107. Continue reading
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Confirming Complexity: Assessing Environmental and Genetic Risk Factors for Inflammatory Bowel Disease
The incidence of inflammatory bowel disease (IBD) is increasing worldwide with the highest incidence rates in westernized countries such as those of northern Europe, the United Kingdom, and North America. These countries share many possible environment… Continue reading
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The Present State and Future Direction of Regenerative Medicine for Perianal Crohn’s Disease
Perianal Crohn’s disease (CD), affecting nearly one-third of patients with CD, is a highly morbid condition owing to incontinence, perianal pain, recurrent infection, and decreased quality of life.1 Notoriously difficult to treat, patients are left c… Continue reading
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