Monthly Archives: July 2019
Lessons Learned From and Future Opportunities for Global Health Endeavors by 2 Academic Gastroenterology Units
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Ver(s)ifying the efficacy of vedolizumab therapy on mucosal healing in Crohn’s disease patients
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Roseburia ssp.: Prime Candidates for Microbial Therapeutics in Inflammatory Bowel Disease
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Increased Risk for Hepatocellular Carcinoma Persists Up to 10 Years After HCV Eradication in Patients with Baseline Cirrhosis or High FIB-4 Scores
It is unclear if hepatocellular carcinoma (HCC) risk declines over time after hepatitis C virus (HCV) eradication. We analyzed changes in HCC annual incidence over time following HCV eradication and identified dynamic markers of HCC risk. Continue reading
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Interferon lambda Promotes Paneth Cell Death via STAT1 Signaling in Mice and is Increased in Inflamed Ileal Tissues of Patients with Crohn’s Disease
Interferon lambda (IFNL) is expressed at high levels by intestinal epithelial cells (IECs) and mucosal immune cells in response to infection and inflammation. We investigated whether IFNL might contribute to pathogenesis of Crohn´s disease (CD). Continue reading
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Fibrogenic Activity of MECP2 is Regulated by Phosphorylation in Hepatic Stellate Cells
Methyl-CpG binding protein 2 (MECP2), which binds to methylated regions of DNA to regulate transcription, is expressed by hepatic stellate cells (HSCs) and is required for development of liver fibrosis in mice. We investigated the effects of MECP2 dele… Continue reading
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AGA Technical Review on the Evaluation of Functional Diarrhea and Diarrhea-Predominant Irritable Bowel Syndrome in Adults
The evaluation of patients with chronic watery diarrhea represents a diagnostic challenge for clinicians because organic causes, including inflammatory bowel disease, microscopic colitis, and chronic infection, must be differentiated from functional di… Continue reading
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Oncogenic KRAS Reduces Expression of FGF21 in Acinar Cells to Promote Pancreatic Tumorigenesis in Mice on a High-Fat Diet
Obesity is a risk factor for pancreatic cancer. In mice, a high-fat diet (HFD) and expression of oncogenic KRAS lead to development of invasive pancreatic ductal adenocarcinoma (PDAC) by unknown mechanisms. We investigated how oncogenic KRAS regulates … Continue reading
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Evolving trends in machine liver perfusion: comments on clinical endpoints and selection criteria
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False-positive fecal immunochemical tests in users of new anticoagulants
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