The quality of bowel preparation for inpatient colonoscopies is frequently poor. Many factors may account for this, including system-level issues such as varying and non-standardized methods of prep administration by covering providers. Quality improvement (QI) interventions focused on regimenting this process might impact both inpatient bowel prep quality and related healthcare outcomes. Therefore, we utilized Six Sigma principles in order to characterize the problem of inadequate inpatient preps, reduce resource utilization, and improve provider satisfaction.