Stenosis is a common complication of Crohn’s disease (CD) that has no effective medical therapy. Development of anti-fibrotic agents will require testing in randomized controlled trials. Computed tomography enterography- and magnetic resonance enterography-based technologies might be used to measure outcomes in these trials. These approaches have been validated in studies of patients with symptomatic strictures who underwent imaging evaluations, followed by resection with histopathologic grading of the intestinal tissue for inflammation and/or fibrosis (the reference standard).