Daily Archives: October 5, 2019

Efficacy of Dupilumab in a Phase 2 Randomized Trial of Adults With Active Eosinophilic Esophagitis

Posted on October 5, 2019 by Gastroenterology Journal

Eosinophilic esophagitis (EoE) is an allergen-mediated inflammatory disease with no approved treatment in the United States. Dupilumab, a VelocImmune-derived human monoclonal antibody against the interleukin 4 (IL4) receptor, inhibits IL4 and IL13 sign… Continue reading →

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Response to LTE 19-01163

Posted on October 5, 2019 by Gastroenterology Journal
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Application of Artificial Intelligence to Gastroenterology and Hepatology

Posted on October 5, 2019 by Gastroenterology Journal

Since 2010, substantial progress has been made in artificial intelligence (AI) and its application to medicine. AI is explored in gastroenterology for endoscopic analysis of lesions, in detection of cancer, and to facilitate the analysis of inflammator… Continue reading →

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NLRP3 Inflammasome Regulates Development of Systemic Inflammatory Response and Compensatory Anti-inflammatory Response Syndromes in Mice With Acute Pancreatitis

Posted on October 5, 2019 by Gastroenterology Journal

Pancreatitis starts with primarily sterile local inflammation that induces systemic inflammatory response syndrome (SIRS) followed by compensatory anti-inflammatory response syndrome (CARS). We investigated mechanisms of these processes in mice and hum… Continue reading →

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Proliferation and Differentiation of Gastric Mucous Neck and Chief Cells During Homeostasis and Injury-induced Metaplasia

Posted on October 5, 2019 by Gastroenterology Journal

Adult zymogen-producing (zymogenic) chief cells (ZCs) in the mammalian gastric gland base are believed to arise from descending mucous neck cells, which arise from stem cells. Gastric injury, such as from Helicobacter pylori infection in patients with … Continue reading →

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