Daily Archives: October 14, 2019

TIME TRENDS IN ADHERENCE TO SURVEILLANCE INTERVALS AND BIOPSY PROTOCOL AMONG PATIENTS WITH BARRETT’S ESOPHAGUS

Posted on October 14, 2019 by Gastroenterology Journal
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Identification and validation of microRNA profiles in fecal samples for detection of colorectal cancer

Posted on October 14, 2019 by Gastroenterology Journal

Screening for colorectal cancer (CRC) is effective in average-risk population. The most extended strategy in organized programs involves the fecal immunochemical test, which is limited by low sensitivity for detection of advanced adenomas (AAs). We aim… Continue reading →

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Precision Treatment and Prevention of Colorectal Cancer—Hope or Hype?

Posted on October 14, 2019 by Gastroenterology Journal
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Pathways of Colorectal Carcinogenesis

Posted on October 14, 2019 by Gastroenterology Journal

Colorectal cancer is a heterogeneous disease that develops via stepwise accumulation of well-characterized genetic and epigenetic alterations. We review the genetic changes associated with the development of pre-cancerous colorectal adenomas and their … Continue reading →

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International Perspective on the Burden of Colorectal Cancer and Public Health Effects

Posted on October 14, 2019 by Gastroenterology Journal
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NUCLEOS(T)IDE ANALOG THERAPY OF CHRONIC HEPATITIS B AND LIVER CANCER RISK REDUCTION: BETTER NUCLEOTIDES THAN NUCLEOSIDES?

Posted on October 14, 2019 by Gastroenterology Journal
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Chromosome Engineering of Human Colon-Derived Organoids to Develop a Model of Traditional Serrated Adenoma

Posted on October 14, 2019 by Gastroenterology Journal

Traditional serrated adenomas (TSAs) are rare colorectal polyps with unique histologic features. Fusions in R-spondin genes have been found in TSAs, but it is not clear whether these are sufficient for TSA development, due to the lack of a chromosome e… Continue reading →

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Therapeutic Targeting of the Colorectal Tumor Stroma

Posted on October 14, 2019 by Gastroenterology Journal

Colorectal tumors have been classified based on histologic factors, genetic factors, and consensus molecular subtypes, which all affect the tumor microenvironment (TME). Elements of the TME serve as therapeutic targets and might be used as prognostic f… Continue reading →

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Identification of a γc Receptor Antagonist that Prevents Reprogramming of Human Tissue-resident Cytotoxic T Cells by IL15 and IL21

Posted on October 14, 2019 by Gastroenterology Journal

Gamma chain (γc) cytokines (interleukin 2 [IL2], IL4, IL7, IL9, IL15 and IL21) signal via a common γc receptor. IL2 regulates the immune response, whereas IL21 and IL15 contribute to development of autoimmune disorders, including celiac disease. We i… Continue reading →

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