Monthly Archives: November 2019

Barrett’s esophagus (BE) is the only known precursor to esophageal adenocarcinoma (EAC), a cancer associated with a dismal 5-year survival rate (Am J Gastroenterol 2017;112(7):1032-1048). Despite all the advances in this field, we have had minimal im… Continue reading →

Approximately 35% of patients with colorectal cancer (CRC) have a family history of the disease, due to genetic factors, common exposures, or both. Some families with a history of CRC carry genetic variants that cause CRC with high or moderate penetran… Continue reading →

We aimed to develop and validate a deep-learning computer-aided detection (CAD) system, suitable for use in real time in clinical practice, to improve endoscopic detection of early neoplasia in patients with Barrett’s esophagus (BE). Continue reading →

Functions of intestinal stem cells (ISCs) are regulated by diet and metabolic pathways. Hepatocyte nuclear factor 4 (HNF4) are transcription factors that bind fatty acids. We investigated how HNF4 transcription factors regulate metabolism and their fun… Continue reading →

Liver regeneration is impaired in mice with hepatocyte-specific deficiencies in microRNA (miRNA) processing, but it is not clear which miRNAs regulate this process. We developed a high-throughput screen to identify miRNAs that regulate hepatocyte repop… Continue reading →

Screening, followed by colonoscopic polypectomy (or surgery for malignant lesions), prevents incident colorectal cancer and mortality. However, there are variations in effective application of nearly every aspect of the screening process. Screening is … Continue reading →

Each donation made to the #GivingTuesday initiative will be matched dollar for dollar up to $100,000 by the Musicant Family Brain Trust and PNC Bank. Continue reading →