Monthly Archives: January 2020

In addition to Notch and Wnt signaling pathways, energy metabolism also regulates intestinal stem cell (ISC) function. Tumor suppressor and kinase STK11 (also called LKB1) regulates stem cells and cell metabolism. We investigated whether loss of LKB1 a… Continue reading →

Colorectal cancer (CRC) incidence and mortality are increasing among persons in the United States younger than 50 years old, but risk factors associated with early-onset CRC (EOCRC) have not been widely studied. Continue reading →

Forty-five years have passed since Correa et al1 proposed their hypothesis on the histopathological cascade leading to gastric adenocarcinoma claiming that gastric cancer usually resulted from chronic gastritis, subsequently leading to gland loss or at… Continue reading →

Microscopic colitis shares pathogenetic mechanisms with inflammatory bowel disease (IBD). We studied the association between microscopic colitis and risk of incident IBD using data from a nationwide cohort study. Continue reading →

Inhibitors of Janus kinases (JAKs) are being developed for treatment of inflammatory bowel diseases and other immune-mediated diseases. Tofacitinib is effective in treatment of ulcerative colitis, but there are safety concerns. We performed a systemati… Continue reading →

Lay Summary: Some people develop colorectal cancer after a colonoscopy in which a cancer was not detected. Forty-three percent of delays in detection occurred in high-risk patients. We analyzed reasons for the delayed diagnoses, and found 89% to be avo… Continue reading →

Lynch syndrome is caused by alterations in a specific group of genes. Patients with different types of genetic alterations develop adenomas and CRC at different rates, and tumors have specific genetic features. Continue reading →