Monthly Archives: February 2020
Improved Accuracy in Optical Diagnosis of Colorectal Polyps Using Convolutional Neural Networks with Visual Explanations
Narrow-band imaging (NBI) can be used to determine whether colorectal polyps are adenomatous or hyperplastic. We investigated whether an artificial intelligence (AI) system can increase the accuracy of characterizations of polyps by endoscopists of dif… Continue reading
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Validation and Comparison of Tools for Selecting Individuals to Screen for Barrett’s Esophagus and Early Neoplasia
The HUNT tool, M-BERET, or Kunzmann tool should be used rather than gastroesophageal reflux disease symptoms alone for identifying individuals who should be offered screening for esophageal cancer. Continue reading
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Robust, 3-Dimensional Visualization of Human Colon Enteric Nervous System Without Tissue Sectioning
Small, 2-dimensional sections routinely used for human pathology provide limited information about bowel innervation. We developed a technique to image human enteric nervous system (ENS) and other intramural cells in 3 dimensions. Continue reading
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Editing Myosin VB Gene to Create Porcine Model of Microvillus Inclusion Disease, With Microvillus-lined Inclusions and Alterations in Sodium Transporters
Microvillus inclusion disease (MVID) is caused by inactivating mutations in the myosin VB gene (MYO5B). MVID is a complex disorder characterized by chronic, watery, life-threatening diarrhea that usually begins in the first hours to days of life. We de… Continue reading
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TMAVA, a Metabolite of Intestinal Microbes, Is Increased in Plasma From Patients With Liver Steatosis, Inhibits γ-butyrobetaine Hydroxylase, and Exacerbates Fatty Liver in Mice
The authors identified a metabolite produced by intestinal bacteria, TMAVA, that worsens fatty liver disease by reducing production of the amino acid carnitine. Carnitine might therefore be used for treatment of fatty liver. Continue reading
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Pre-treatment Frailty Is Independently Associated With Increased Risk of Infections After Immunosuppression in Patients with Inflammatory Bowel Diseases
Frail patients with IBD have an increased risk of infection after anti-TNF or immunomodulator therapy. Continue reading
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VUMC Infection Prevention continues to monitor coronavirus situation
As the 2019 Novel Coronavirus (SARS-CoV-2 which causes COVID-19) continues to spread, with new cases reported in, among other places, Northern Italy, Iran, Japan, and South Korea, VUMC continues to monitor the outbreak closely. Starting today, the trav… Continue reading
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Five things for employees to know about the COVID-19 coronavirus; five things about coronavirus to tell our patients
While there are currently no individuals in Tennessee who have tested positive for the COVID-19 virus, plans are being finalized that would help manage an influx of patients into our clinics and hospitals. Continue reading
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New Health Plus Wellcast: “Get Active! It’s the Kicker for Your Ticker”
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REDCap introductory training is tomorrow
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