Daily Archives: February 12, 2020

Adipose tissue and the liver play a significant role in the regulation of whole body energy homeostasis, but they have not evolved to cope with the continuous, chronic, nutrient surplus seen in obesity. In this review, we detail how prolonged metabolic… Continue reading →

Lifestyle modifications focused on healthy eating and regular exercise are the primary recommendations for patients with NASH. However, for multiple societal, psychological, physical, genetic, and epigenetic reasons, the ability of people to adopt and … Continue reading →

Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease with a worldwide prevalence of 25%. In the US, NAFLD and its subtype, nonalcoholic steatohepatitis (NASH), affect 30% and 5% of the population, respectively. Considering the ongo… Continue reading →

Circadian clock proteins are endogenous timing mechanisms that control the transcription of hundreds of genes. Their integral role in coordinating metabolism has led to their scrutiny in a number of diseases, including NAFLD. Discoordination between ce… Continue reading →

Concerns regarding the veracity of the images and data presented in the article, “MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer” by Meng F, et al. Gastroenterology 2007;133(2):647–658, were brought to… Continue reading →

Concerns regarding the veracity of the images and data presented in the article, “MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer” by Meng F, et al. Gastroenterology 2007;133(2):647–658, were brought to… Continue reading →