Monthly Archives: February 2020

Study links neural circuit with impaired social function

Stimulating neural activity between the amygdala and the nucleus accumbens — a brain region associated with pleasure — impairs social function even though mice find the stimulation rewarding, a new study published by Vanderbilt researchers in “The Jo… Continue reading

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Diabetes Prevention Program information sessions set for Feb. 25, 26, 27 and 28

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Identification of Subtypes of Barrett’s Esophagus and Esophageal Adenocarcinoma Based on DNA Methylation Profiles and Integration of Transcriptome and Genome Data

Esophageal adenocarcinomas (EAC) are heterogeneous and often preceded by Barrett’s esophagus (BE). Many genomic changes have been associated with development of BE and EAC, but little is known about epigenetic alterations. We performed epigenetic analy… Continue reading

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Gliadin Nanoparticles Induce Immune Tolerance to Gliadin in Mouse Models of Celiac Disease

Celiac disease could be treated, and potentially cured, by restoring T-cell tolerance to gliadin. We investigated the safety and efficacy of negatively charged, 500 nm, poly(lactide-co-glycolide) nanoparticles encapsulating gliadin protein (TIMP-GLIA) … Continue reading

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GPR30-expressing Gastric Chief Cells do not Dedifferentiate but are Eliminated via PDK-dependent Cell Competition During Development of Metaplasia

Gastric chief cells, a mature cell type that secretes digestive enzymes, have been proposed to be the origin of metaplasia and cancer, through dedifferentiation or trans-differentiation. However, studies supporting this claim have had technical limitat… Continue reading

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Association Between Fibrosis Stage and Outcomes of Patients with Non-Alcoholic Fatty Liver Disease: a Systematic Review and Meta-Analysis

Biopsy-confirmed liver fibrosis is a prognostic factor for patients with non-alcoholic fatty liver disease (NAFLD). We performed a systematic review to quantify the prognostic value of fibrosis stage in patients with NAFLD and the subgroup of patients … Continue reading

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Children’s Hospital leadership appointments announced

After serving as interim president of Monroe Carell Jr. Children’s Hospital at Vanderbilt, Meg Rush, MD, MMHC, has been named to permanently fill the role of president. Succeeding Rush in the role as hospital’s chief of staff is John Thomas, MD, associ… Continue reading

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Latest update from VUMC Infection Prevention on 2019 novel coronavirus

VUMC continues to monitor the ongoing 2019 Novel Coronavirus (2019-nCoV) outbreak. We want to highlight important points and resources for VUMC faculty and staff to help address any questions or concerns. Continue reading

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Southern Women’s Show offers Vanderbilt discount

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“Discover”: Adverse pregnancy outcomes in lupus patients

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