Monthly Archives: February 2020
Study links neural circuit with impaired social function
Stimulating neural activity between the amygdala and the nucleus accumbens — a brain region associated with pleasure — impairs social function even though mice find the stimulation rewarding, a new study published by Vanderbilt researchers in “The Jo… Continue reading
Diabetes Prevention Program information sessions set for Feb. 25, 26, 27 and 28
Identification of Subtypes of Barrett’s Esophagus and Esophageal Adenocarcinoma Based on DNA Methylation Profiles and Integration of Transcriptome and Genome Data
Esophageal adenocarcinomas (EAC) are heterogeneous and often preceded by Barrett’s esophagus (BE). Many genomic changes have been associated with development of BE and EAC, but little is known about epigenetic alterations. We performed epigenetic analy… Continue reading
Gliadin Nanoparticles Induce Immune Tolerance to Gliadin in Mouse Models of Celiac Disease
Celiac disease could be treated, and potentially cured, by restoring T-cell tolerance to gliadin. We investigated the safety and efficacy of negatively charged, 500 nm, poly(lactide-co-glycolide) nanoparticles encapsulating gliadin protein (TIMP-GLIA) … Continue reading
GPR30-expressing Gastric Chief Cells do not Dedifferentiate but are Eliminated via PDK-dependent Cell Competition During Development of Metaplasia
Gastric chief cells, a mature cell type that secretes digestive enzymes, have been proposed to be the origin of metaplasia and cancer, through dedifferentiation or trans-differentiation. However, studies supporting this claim have had technical limitat… Continue reading
Association Between Fibrosis Stage and Outcomes of Patients with Non-Alcoholic Fatty Liver Disease: a Systematic Review and Meta-Analysis
Biopsy-confirmed liver fibrosis is a prognostic factor for patients with non-alcoholic fatty liver disease (NAFLD). We performed a systematic review to quantify the prognostic value of fibrosis stage in patients with NAFLD and the subgroup of patients … Continue reading
Children’s Hospital leadership appointments announced
After serving as interim president of Monroe Carell Jr. Children’s Hospital at Vanderbilt, Meg Rush, MD, MMHC, has been named to permanently fill the role of president. Succeeding Rush in the role as hospital’s chief of staff is John Thomas, MD, associ… Continue reading
Latest update from VUMC Infection Prevention on 2019 novel coronavirus
VUMC continues to monitor the ongoing 2019 Novel Coronavirus (2019-nCoV) outbreak. We want to highlight important points and resources for VUMC faculty and staff to help address any questions or concerns. Continue reading