Monthly Archives: June 2020
IRE1A Stimulates Hepatocyte-derived Extracellular Vesicles That Promote Inflammation in Mice With Steatohepatitis
Endoplasmic reticulum to nucleus signaling 1 (ERN1, also called IRE1A) is a sensor of the unfolded protein response that is activated in livers of patients with nonalcoholic steatohepatitis (NASH). Hepatocytes release ceramide-enriched inflammatory ext… Continue reading
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Is heterozygosity for the alpha-1 antitrypsin risk allele Pi*MZ disease modifier or genetic risk factor?
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Read the transcript from Dr. Balser’s video message
Hello everyone. Today is Juneteenth — an important day in American history. It was this day on June 19, 1865, when the last group of enslaved Africans held in Texas were freed, years after Lincoln issued the Emancipation Proclamation. It took far too … Continue reading
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Message from Dr. Jeff Balser, President and CEO, about recognizing the need for change and stepping up at this moment in history
Dr. Jeff Balser talks about how VUMC has responded to the pandemic, how our institution can help our region to a healthier and more just future, and how each of us at VUMC can make our voices heard as we build that future together. Continue reading
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Altered Gut Archaea Composition and Interaction with Bacteria are Associated with Colorectal Cancer
Changes in the intestinal microbiota have been associated with development and progression of colorectal cancer (CRC). Archaea are stable components of the microbiota, but little is known about their composition or contribution to colorectal carcinogen… Continue reading
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Diffuse Pancreas Swelling in a Patient with Multiple Myeloma
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A life-threatening complication of upper endoscopy
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Utility of Surveillance and Screening Colonoscopy in Older Adults
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Loss of NFKB1 Results in Expression of Tumor Necrosis Factor and Activation of STAT1 to Promote Gastric Tumorigenesis in Mice
Activity of NFkB transcription factors and signaling via STAT are frequently altered in gastric cancer cells. Mice lacking NFKB1 (Nfkb1–/– mice) develop invasive gastric cancer and their gastric tissues have increased levels of cytokines, such as inter… Continue reading
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