Daily Archives: August 16, 2020
Transcription and DNA Methylation patterns of blood derived CD8+ T cells are associated with age and Inflammatory Bowel Disease but do not predict prognosis
Gene expression patterns of CD8+ T cells have been reported to correlate with clinical outcomes of adults with inflammatory bowel diseases (IBD). We aimed at validating these findings in independent patient cohorts. Continue reading
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Cooperation between distinct cancer driver genes underlies inter-tumor heterogeneity in hepatocellular carcinoma
The pattern of genetic alterations in cancer driver genes in patients with hepatocellular carcinoma (HCC) is highly diverse, which partially explains the low efficacy of available therapies. In spite of this, the existing mouse models only recapitulate… Continue reading
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In Colorectal Cancer Cells With Mutant KRAS, SLC25A22-Mediated Glutaminolysis Reduces DNA Demethylation to Increase WNT Signaling, Stemness, and Drug Resistance
Mutant KRAS promotes glutaminolysis, a process that uses steps from the tricarboxylic cycle to convert glutamine to α-ketoglutarate and other molecules, via glutaminase and solute carrier family 25 member 22 (SLC25A22). This results in inhibition of de… Continue reading
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