Monthly Archives: August 2020

Gene expression patterns of CD8+ T cells have been reported to correlate with clinical outcomes of adults with inflammatory bowel diseases (IBD). We aimed at validating these findings in independent patient cohorts. Continue reading →

The pattern of genetic alterations in cancer driver genes in patients with hepatocellular carcinoma (HCC) is highly diverse, which partially explains the low efficacy of available therapies. In spite of this, the existing mouse models only recapitulate… Continue reading →

Mutant KRAS promotes glutaminolysis, a process that uses steps from the tricarboxylic cycle to convert glutamine to α-ketoglutarate and other molecules, via glutaminase and solute carrier family 25 member 22 (SLC25A22). This results in inhibition of de… Continue reading →

This document presents the official recommendations of the American Gastroenterological Association (AGA) on the gastrointestinal evaluation of iron deficiency anemia (IDA). The guideline was developed by the AGA Institute’s Clinical Guidelines Committ… Continue reading →

Chromosomal instability (CIN) is a carcinogenesis event that promotes metastasis and resistance to therapy, by unclear mechanisms. Expression of the colon cancer associated transcript 2 gene (CCAT2), which encodes a long noncoding RNA (lncRNA), associa… Continue reading →

After birth, the immune system matures via interactions with microbes in the gut. The S100 calcium binding proteins S100A8 and S100A9, and their extracellular complex form, S100A8–A9, are found in high amounts in human breast milk. We studied levels of… Continue reading →

A roundup of a few recent stories from the press about Vanderbilt University Medical Center. Continue reading →