Monthly Archives: August 2020
Efficacy and Safety of Aldafermin, an Engineered FGF19 Analog, in a Randomized, Double-Blind, Placebo-Controlled Trial of Patients With Nonalcoholic Steatohepatitis
Aldafermin, an engineered analog of FGF19, inhibits bile acid synthesis and regulates metabolic homeostasis. We report results from a 24-week, phase 2 study, with serial liver biopsies, of patients with non-alcoholic steatohepatitis (NASH). Continue reading
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PAF1 Regulates Stem Cell Features of Pancreatic Cancer Cells, Independently of the PAF1 Complex, via Interactions with PHF5A and DDX3
It is not clear how pancreatic cancer stem cells (CSCs) are regulated, resulting in ineffective treatments for pancreatic cancer. PAF1, a RNA polymerase II-associated factor 1 complex (PAF1C) component, maintains pluripotency of stem cells, by unclear … Continue reading
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Outcomes of Pregnant Women With Cirrhosis and Their Infants in a Population-Based Study
The incidence of cirrhosis is increasing among women of childbearing age. Contemporary outcomes of pregnant women with cirrhosis and their infants, and liver-related complications, have not been described in North America. We investigated the associati… Continue reading
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A Rare and Atypical Complication of Chronic Pancreatitis
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Early onset esophageal adenocarcinoma presents with advanced stage disease but has improved survival compared with older individuals
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Population-based Analysis of Differences in Gastric Cancer Incidence Among Races and Ethnicities in Individuals Age 50 Years and Older
There are racial and ethnic differences in the incidence of gastric adenocarcinoma worldwide and in the United States. Based on a decision analysis, screening for noncardia gastric adenocarcinoma might be cost effective for non-white individuals age 50… Continue reading
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Pancytopenia in a Young Male Patient with Inflammatory Bowel Disease
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Presence of SARS-Coronavirus-2 in the ileal mucosa: another evidence for infection of GI tract by this virus
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Low Risk of Advanced Neoplasms for up to 20 Years after Negative Colonoscopy: Potential for Personalized Follow-up Screening Intervals
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Life-threatening diarrhea in an elderly patient
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