Monthly Archives: September 2020
Steatohepatitis Impairs T cell-directed Immunotherapies Against Liver Tumors in Mice
Non-alcoholic steatohepatitis causes loss of hepatic CD4+ T cells and promotes tumor growth. The liver is the most common site of distant metastases from a variety of malignancies, many of which respond to immunotherapy. We investigated the effects of … Continue reading
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IL-33 triggers early eosinophil-dependent events leading to metaplasia in a chronic model of gastritis-prone mice
IL-33/IL-1F11 is an important mediator for the development of Th2-driven inflammatory disorders and has also been implicated in the pathogenesis of GI-related cancers, including gastric carcinoma. We therefore sought to mechanistically determine IL-33’… Continue reading
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Epidemiologic Burden and Treatment of Chronic Symptomatic Functional Bowel Disorders in the United States: A Nationwide Analysis
Functional bowel disorders (FBDs) are the most common gastrointestinal problems managed by physicians. We aimed to assess the burden of chronic symptomatic FBDs on ambulatory care delivery in the United States and evaluate patterns of treatment. Continue reading
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AGA Clinical Practice Update on the Evaluation and Management of Seronegative Enteropathies
We aim to provide a consensus statement for the best approaches for diagnosis and management of patients with suspected enteropathy but negative results from serologic tests for celiac disease (seronegative enteropathy). Continue reading
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Covid19 and the gastrointestinal tract: lessons learned from human organoids
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AGA Clinical Practice Update on Management of Inflammatory Bowel Disease in the Elderly: Expert Review
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Could a small population of epithelial cells get “tuft” with Crohn’s disease?
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“Discover”: Targeting mitochondrial dysfunction to ease CKD complications
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2020 VUMC Chill Out facts and stats
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