Monthly Archives: September 2020
INTESTINAL MICROBIOME MODULATION DURING COVID-19: ANOTHER CHANCE TO MANAGE THE DISEASE?
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Obesity and mortality in COVID-19: cause or association?
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An unusual cause of small intestinal ulceration
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Uncommon Cause of Emesis and Diarrhea in a Non-verbal Elderly Patient
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Clinical Challenges and Images in GI: An unsuspected cause of rectal bleeding
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A rare non recognized cause of dysphagia
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From birth to overweight and atopic disease: multiple and common pathways of the infant gut microbiome
Few studies, even those with cohort designs, test the mediating effects of infant gut microbes and metabolites on the onset of disease. We undertook such a study. Methods: Using SEM path analysis, we tested directional relationships between first pregn… Continue reading
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ALTERATIONS IN GUT MICROBIOME IN CIRRHOSIS AS ASSESSED BY QUANTITATIVE METAGENOMICS. RELATIONSHIP WITH ACUTE-ON-CHRONIC LIVER FAILURE AND PROGNOSIS
Cirrhosis is associated with changes in gut microbiome composition. Although ACLF is the most severe clinical stage of cirrhosis, there is lack of information about gut microbiome alterations in ACLF using quantitative metagenomics. To investigate the … Continue reading
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Expression of R-spondin1 in ApcMin/+ Mice Reduces Growth of Intestinal Adenomas by Altering Wnt and TGFB Signaling
Mutations in the APC gene and other genes in the Wnt signaling pathway contribute to development of colorectal carcinomas. R-spondins (RSPOs) are secreted proteins that amplify Wnt signaling in intestinal stem cells. Alterations in RSPO genes have been… Continue reading
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Reduction of squalene epoxidase by cholesterol accumulation accelerates colorectal cancer progression and metastasis.
Squalene epoxidase (SQLE), a rate-limiting enzyme in cholesterol biosynthesis, is suggested as a proto-oncogene. Paradoxically, SQLE is degraded by excess cholesterol, and low SQLE is associated with aggressive colorectal cancer (CRC). Therefore, we st… Continue reading
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