Daily Archives: November 13, 2020
The balance of stromal BMP signaling mediated by GREM1 and ISLR drives colorectal carcinogenesis.
Cancer-associated fibroblasts (CAF), key constituents of the tumor microenvironment, either promote or restrain tumor growth. Attempts to therapeutically target CAFs have been hampered by our incomplete understanding of these functionally heterogeneous… Continue reading
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Dicarbonyl Electrophiles Mediate Inflammation-Induced Gastrointestinal Carcinogenesis
Inflammation in the gastrointestinal tract may lead to the development of cancer. Dicarbonyl electrophiles, such as iso-levuglandins (isoLGs), are generated from lipid peroxidation during the inflammatory response, and form covalent adducts with amine-… Continue reading
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Association between pre-admission acid suppressive medication exposure and severity of illness in patients hospitalized with COVID-19
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Plasmid acquisition alters vancomycin susceptibility in Clostridioides difficile
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A novel role of SLC26A3 in maintenance of intestinal epithelial barrier integrity
The Down Regulated in Adenoma (DRA) encoded by SLC26A3, a key intestinal chloride anion exchanger, has recently been identified as a novel susceptibility gene for inflammatory bowel disease (IBD). However, the mechanisms underlying the increased suscep… Continue reading
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