Monthly Archives: February 2021
Gut microbiota perturbation in IgA deficiency is influenced by IgA-autoantibody status
Immunoglobulin A (IgA) exerts its primary function at mucosal surfaces where it binds microbial antigens to regulate bacterial growth and epithelial attachment. One-third of individuals with IgA deficiency (IgAD) suffer from recurrent mucosal infection… Continue reading
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The rs738409 G allele in PNPLA3 is associated with a reduced risk of COVID-19 mortality and hospitalisation.
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Molecular-based Helicobacter pylori susceptibility testing is almost ready for prime time.
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Squalene epoxidase induces nonalcoholic steatohepatitis via binding to carbonic anhydrase 3 and is a therapeutic target
Squalene epoxidase (SQLE) is the rate-limiting enzyme for cholesterol biosynthesis. We elucidated the functional significance, molecular mechanisms and clinical impact of SQLE in non-alcoholic steatohepatitis (NASH). Continue reading
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Circulating Tumor DNA Detection Using Digital Polymerase Chain Reaction—Promising But Needs Improvement
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Direct Measurement of ATP7B Peptides is Highly Effective in the Diagnosis of Wilson Disease
Both existing clinical criteria and genetic testing have significant limitations for the diagnosis of Wilson’s Disease (WD) often creating ambiguities in patient identification leading to delayed diagnosis and ineffective management. ATP7B protein conc… Continue reading
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In CRC Screening, Timing is Almost Everything
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Inclusion of carcinoids in early onset colorectal tumor incidence rates: Adenocarcinoma in young adults still the major problem
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iPSC-derived hepatocytes from patients with nonalcoholic fatty liver disease display a disease-specific gene expression profile
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Response to: Olesen SW, “Fecal microbiota transplantation “donor effects” are not clinically relevant for Clostridioides difficile infection.”
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