Crohn’s Disease (CD) is an Inflammatory Bowel Disease (IBD) whose etiology has been suspected to include bacterial antigens. A treatment option, therefore, would be the usage of antibiotics. To that end, the purpose of this study was to perform a meta-analysis on the ability of antibiotics inducing remission or a favorable clinical response in Crohn’s disease (CD) patients. Thirty-two randomized, double-blind, placebo-controlled trials of antibiotics for treatment of CD in adults, totaling 3269 patients, were reviewed.