The Inflammation, Microbiome, & Alimentation, Gastro-Intestinal & Neuropsychiatric Effects (IMAGINE) Strategy for Patient-Oriented Research (SPOR) Network is conducting a large longitudinal research study to investigate the interactions between inflammation, microbiome, diet, and mental health in patients with inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). This study aims to recruit 2000 patients with Crohn’s disease, 2000 with ulcerative colitis, 2000 with IBS, and 2000 healthy controls.