Daily Archives: March 18, 2021
Sequential administration of XPO1 and ATR inhibitors enhances therapeutic response in TP53-mutated colorectal cancer
Understanding the mechanisms by which tumors adapt to therapy is critical for developing effective combination therapeutic approaches to improve clinical outcomes for patients with cancer. Continue reading
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Does endoscopic screening really not alter the incidence of gastric cancer?
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Adenocarcinomas, as opposed to carcinoids, are primarily driving increases in early-onset colorectal cancer rates
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Expanding the diagnostic toolkit of Wilson disease with ATP7B peptides
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Is IL-6 back in trans signalling for inflammatory bowel disease?
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COVID-19 gastrointestinal symptoms and attenuation of the immune response to SARS-CoV-2
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Neutrophils Alter DNA Repair Landscape to Impact Survival and Shape Distinct Therapeutic Phenotypes of Colorectal Cancer
Tumor-infiltrating neutrophils (PMNs) are a prominent feature of colorectal cancer (CRC), where they can promote cytotoxicity or exacerbate disease outcomes. We recently showed that in acute colon injury, PMNs can increase DNA double-strand breaks (DSB… Continue reading
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