Monthly Archives: March 2021
Randomized Controlled Trial: Subcutaneous versus Intravenous Infliximab CT-P13 Maintenance in Inflammatory Bowel Disease
This study compared pharmacokinetics, symptomatic and endoscopic efficacy, safety, and immunogenicity of a subcutaneous formulation of the infliximab biosimilar CT-P13 (CT-P13 SC) versus intravenous CT-P13 (CT-P13 IV) in inflammatory bowel disease (IBD… Continue reading
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X chromosome contribution to the genetic architecture of primary biliary cholangitis
Genome-wide association studies (GWAS) in primary biliary cholangitis (PBC) have failed to find X chromosome (chrX) variants associated with the disease. Here, we specifically explore the chrX contribution to PBC, a sexually-dimorphic complex autoimmun… Continue reading
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Commentary on the AGA Clinical Practice Guidelines on the Gastrointestinal Evaluation of Iron Deficiency Anemia
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Therapeutic IL-6 trans-signalling inhibition by olamkicept (sgp130Fc) in patients with active inflammatory bowel disease
A large unmet therapeutic need exists in inflammatory bowel diseases (IBD). Inhibition of interleukin (IL)-6 appears to be effective, but the therapeutic benefit of a complete IL-6/IL-6R blockade is limited by profound immunosuppression. Evidence has e… Continue reading
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B lymphocytes contribute to celiac disease pathogenesis
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Impact of COVID-19 Pandemic on Gastrointestinal Procedures and Cancers in the United States. A Multicenter Research Network Study.
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Impact of COVID-19 Pandemic on Gastrointestinal Procedures and Cancers in the United States. A Multicenter Research Network Study.
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Induction and long-term follow-up with ABX464 for moderate-to-severe ulcerative colitis: Results of phase 2a trial
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Six versus twelve sessions of gut-focused hypnotherapy for irritable bowel syndrome: a randomized trial
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Serotonin Deficiency is Associated with Delayed Gastric Emptying
Gastrointestinal (GI) motility is regulated by serotonin (5-hydroxytryptamine, 5-HT), which is primarily produced by enterochromaffin (EC) cells in the GI tract. However, the precise roles of EC cell-derived 5-HT in regulating gastric motility remain a… Continue reading
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