Daily Archives: April 2, 2021
In Memoriam for Donald O. Castell, M.D.
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Intestinal Sulfation is Essential to Protect Against Colitis and Colonic Carcinogenesis
Sulfation is a conjugation reaction essential for numerous biochemical and cellular functions in mammals. The 3′-phosphoadenosine 5′-phosphosulfate (PAPS) synthase 2 (PAPSS2) is the key enzyme to generate PAPS, which is the universal sulfonate donor fo… Continue reading
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A Liquid Biopsy Assay for Noninvasive Identification of Lymph Node Metastases in T1 Colorectal Cancer
We recently reported use of tissue-based transcriptomic biomarkers (miRNA or mRNA) for identification of lymph node metastasis (LNM) in patients with invasive submucosal colorectal cancers (T1 CRC). In this study, we translated our tissue-based biomark… Continue reading
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Epithelia-sensory neuron crosstalk underlies cholestatic itch induced by lysophosphatidylcholine
Limited understanding of pruritus mechanisms in cholestatic liver diseases hinders development of anti-pruritic treatments. Previous studies implicated lysophosphatidic acid (LPA) as a potential mediator of cholestatic pruritus. Continue reading
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BCL3 couples cancer stem cell enrichment with pancreatic cancer molecular subtypes
The existence of different subtypes of pancreatic ductal adenocarcinoma (PDAC) and their correlation with patient outcome have shifted the emphasis on patient classification for better decision-making algorithms and personalized therapy. The contributi… Continue reading
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BMP pathway antagonism by Grem1 regulates epithelial cell fate in intestinal regeneration
In homeostasis, intestinal cell fate is controlled by balanced gradients of morphogen signalling. The Bone Morphogenetic Protein (BMP) pathway has a physiological, pro-differentiation role, predominantly inferred through previous experimental pathway i… Continue reading
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