Daily Archives: April 9, 2021
Fecal microbiota transplantation for recurrent Clostridioides difficile infection associates with functional alterations in circulating microRNAs
The molecular mechanisms underlying successful fecal microbiota transplantation (FMT) for recurrent Clostridioides difficile infection (rCDI) remain poorly understood. The primary objective of this study was to characterize alterations in microRNAs (mi… Continue reading
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A gut-intrinsic melanocortin signalling complex augments L cell secretion in humans
Hypothalamic melanocortin 4 receptors (MC4R) are a key regulator of energy homeostasis. Brain-penetrant MC4R agonists have failed, as concentrations required to suppress food intake also increase blood pressure. However, peripherally located MC4R may a… Continue reading
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Human microbiota flagellins drive adaptive immune responses in Crohn’s disease
Crohn’s Disease (CD) and ulcerative colitis (UC) are characterized by dysregulated adaptive immune responses to the microbiota in genetically susceptible individuals, but the specificity of these responses remains largely undefined. Therefore, we devel… Continue reading
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Covering the Cover
Healthy cotwins share gut microbiome signatures with their inflammatory bowel disease twins and unrelated patients Continue reading
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