Providing high-quality care resulting in optimal outcomes and patient satisfaction is the goal of every practicing clinician. The production of evidence-based clinical guidelines is essential in this pursuit, especially when they are linked with implementation efforts, such as clinical decision support tools and practice improvement modules. In this issue of Gastroenterology, the American Gastroenterological Association (AGA) has published an updated guideline on the medical management of moderate to severe Crohn’s disease (CD).