Daily Archives: July 22, 2021

PATHOPHYSIOLOGY AND BIOMARKER POTENTIAL OF FATTY ACID ETHYL ESTER ELEVATION DURING ALCOHOLIC PANCREATITIS

Posted on July 22, 2021 by Gastroenterology Journal

The role of fatty acid ethyl esters (FAEEs) during human alcoholic pancreatitis is unknown. We compared FAEE levels to their non-esterified fatty acids (NEFA) precursors during alcohol intoxication and clinical alcoholic pancreatitis. The pathophysiolo… Continue reading →

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AGR2-dependent nuclear import of RNA polymerase II constitutes a specific target of pancreatic ductal adenocarcinoma in the context of wild-type p53

Posted on July 22, 2021 by Gastroenterology Journal

Promoted by pancreatitis, oncogenic KrasG12D triggers acinar cells’ neoplastic transformation through acinar-to-ductal metaplasia (ADM) and pancreatic intraepithelial neoplasia (PanIN). Agr2 (anterior gradient 2), a known inhibitor of p53, is detected … Continue reading →