775c A Phase 2 Randomized Controlled Trial Demonstrating the Efficacy and Safety of Shr0302, A Selective JAK1 Inhibitor for the Treatment of Moderate to Severe Ulcerative Colitis Patients.

SHR0302 is a selective JAK1 inhibitor. A global, randomized, placebo-controlled phase 2 study (AMBER2; NCT03675477) consisting of an 8-week induction + 8-week extension period, was conducted to evaluate the efficacy and safety of SHR0302 in moderate to severe ulcerative colitis patients. We present the 8-week induction results.