Neurotropic herpes viruses establish lifelong latent infections in ganglionic neurons, including intrinsic enteric neurons and extrinsic neurons that project to the GI tract. Upon reactivation, virus replication within innervated tissues can result in enteric disorders such as herpetic gastritis, esophagitis, and enteric zoster. In animal models, enteric neuronal infection results in gut dysmotility, indicating herpesviruses may play a role in functional gastrointestinal disorders (FGIDs). Neurotropic herpesviruses have also been theorized to contribute to fibromyalgia (FM), a functional somatic syndrome frequently comorbid with IBS and other FGIDs.